Dr Fred Frasch
Research Physical Scientist, Coordinator, Infectious, Immune and Dermal Cross Sector
US National Institute for Occupational Safety and Health
Dr Fred Frasch will be a Keynote presenter at the 7th Occupational and Environmental Exposure of Skin to Chemicals (OEESC) Conference. He will be speaking on the ‘Systemic Uptake of Chemicals from Dermal Exposure’.
Dr. Frasch heads a dermal exposure research team at the US National Institute for Occupational Safety and Health (NIOSH), where he is also Coordinator of the Infectious, Immune and Dermal cross sector of the NIOSH Program Portfolio. His research is focused on mechanistic understanding of the dermal absorption process, particularly as it relates to occupational skin exposures. He will speak on the Systemic Uptake of Chemicals from Dermal Exposure.
Exposure assessment models rely on in vitro experimental data to estimate systemic uptake. This talk will focus on experimental design and interpretation of data from these experiments and will discuss the applicability of in vitro exposures to “real world” exposure scenarios. Specifically, three archetypal exposures will be considered: infinite dose, transient exposure, and finite dose. International regulatory and advisory agencies have published guidelines on the conduct of in vitro experiments, but insufficient guidance has been provided on the interpretation of data from these experiments. Examples, pitfalls and cautionary tales will be provided which should be considered in the assessment of risk from dermal exposure.
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